
Esketamine is a prescription-only drug that has been shown to be effective in treating depression that other forms of medication treatment haven’t helped. It is a nasal spray for depression—the first of its kind—and was FDA-approved for treatment-resistant depression in 2019. Esketamine is given in an outpatient clinic setting where you are closely monitored during your session by trained healthcare professionals.
If you’d like more information, you can read more on esketamine (Spravato) in this patient brochure.
Patients can experience a variety of feelings during an esketamine treatment. The most intense feelings/experiences happen soon after taking esketamine, and usually dissipate by 30-45 minutes. Patients may experience:
The idea of "leaning into the experience" means being open and accepting of the unique sensations and thoughts that may occur during and after your esketamine treatment. These experiences are temporary and part of the treatment process.
Remember: You are in a supportive environment with trained healthcare professionals. Our clinical rooms were specially designed to be comfortable, quiet, and with adjustable lighting. The rooms don’t feel clinical but are more like a living room for your comfort. You will be closely monitored and released when medically ready. You aren’t alone

Anschutz Health Sciences Building
1890 North Revere Court, Suite 5240
Aurora, CO 80045
Parking: We provide short term parking on the north side of the building.
Phone: 303-724-6004
Email: DOP.PsychNAT@cuanschutz.edu
1809 N Revere Ct
Suite 5240
Mail Stop F546
Aurora, CO 80045
Center Hours: 8:00AM - 5:00PM
Current Patients: 303-724-3300
New Patients: 303-724-4975
Fax: 303-724-4698
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